You wake up in your Chicago apartment, look out at the gray sky, and already feel tired. Maybe you drag yourself through the workday, snap at people you care about, and have no interest in sex. You are not sure if this is low testosterone and depression, stress, or just another long winter near the lake.
For many women, the symptoms blur together. Low testosterone and depression can look and feel very similar. Both can drain your energy, steal your joy, and leave you feeling unlike yourself.
Women have testosterone too, not just men. Your levels can shift around perimenopause, menopause, and after childbirth, which can change your mood, sleep, and sex drive. At a practice like the Women’s Health Center of Chicago, your OB-GYN can look at both your mental health and your hormones so you get a plan that fits your whole life, not just one piece of it.
Low Testosterone vs Depression: How They Feel the Same

Low testosterone and depression often walk side by side. That is why it can be so hard to tell them apart on your own.
Both can make you feel like someone turned down the dimmer switch on your life. Colors seem duller, your body feels heavier, and even simple tasks take more effort.
Shared symptoms that make low T and depression easy to mix up
These symptoms can show up in both men and women:
- Low energy and constant tiredness, even after sleep
- Less interest in sex or touch
- Feeling down, numb, or “flat”
- Brain fog or trouble focusing
- Sleep problems, such as waking at 3 a.m. and staring at the ceiling
- Less interest in hobbies, food, or social time you used to enjoy
If you live in Chicago, long dark winters and busy work schedules can add to all this. You might blame everything on stress or weather and miss that your hormones, your mood, or both are also playing a role.
The overlap can be confusing. For example, low testosterone can cause fatigue, low sex drive, and brain fog. Depression can cause the same issues. You might think, “I am just burned out,” when your body is also asking for hormone testing.
These symptoms are real, not in your head. Knowing that they can come from more than one cause is the first step toward the right help.
What low testosterone looks like in women compared to depression
In women, low testosterone often shows up during perimenopause and menopause, or sometimes after childbirth. Hormones can swing a lot, then settle at lower levels.
Low testosterone in women may look like:
- Lower sex drive than usual
- Vaginal dryness
- Pain or discomfort with sex
- Less muscle tone, or feeling physically weaker
- Changes in body hair or weight that surprise you
These changes can pile on top of mood shifts. You might feel irritable, weepy, or “not yourself,” which can feel very close to depression.
Classic depression, however, tends to include:
- Feeling hopeless or empty most days
- Not enjoying almost anything, even when you try
- Big changes in appetite or weight
- Guilt or worthlessness that will not lift
- Thoughts of self harm or that life is not worth living
Those deeper, darker thoughts are tied more to depression than to low testosterone alone. Low T can lower your mood, but it does not explain everything by itself.
If your symptoms started around perimenopause or menopause and you are not sure what is normal, it can help to read about the differences between perimenopause and menopause, then bring your questions to your OB-GYN.
Key Differences: How to Tell Low Testosterone and Depression Apart
You should not try to diagnose yourself at home, but you can notice patterns. Those patterns help your OB-GYN sort out what is going on.
Doctors look at three main things: your body symptoms, your mood symptoms, and your lab tests. They also look at timing, such as whether you are near menopause, just had a baby, or went through a major life stress.
Body clues that point more to low testosterone than depression
Some signs point more toward hormone shifts than mood alone, especially in women around menopause:
- Hot flashes and night sweats
- Vaginal dryness or pain with sex
- Ongoing low libido
- Loss of muscle strength or tone
- New chin hair or thinning hair on your scalp
- Weight gain around your belly that does not match your usual habits
These can happen along with changes in estrogen, progesterone, and thyroid hormones. Your body is doing a lot of adjusting at once.
If you see these patterns, that is a reason to see a women’s health specialist in Chicago for proper testing, not a reason to grab over the counter hormone products. A guide on physical and emotional menopause symptoms can give you more context before your visit.
Mood clues that point more to depression than just low T
Other signs raise more concern about depression:
- Feeling sad, empty, or hopeless most of the day
- Strong guilt, shame, or worthlessness
- Pulling away from friends and family
- Trouble getting basic tasks done at work, school, or home
- Thoughts about death, wishing you would not wake up, or self harm
Low testosterone can affect your mood, but when these heavier, lasting symptoms show up, mental health care becomes very important.
If you ever have thoughts of harming yourself or feel you are in danger, call 988, 911, or go to the nearest emergency room right away. Your safety matters more than any label or diagnosis.
Why low testosterone and depression can happen together
Your hormones and your brain talk to each other all day. Testosterone helps support motivation, focus, and stable mood. When levels drop, brain chemicals that affect mood can shift too.
Research in recent years shows:
- Women with lower testosterone, especially after menopause, have a higher risk of depression
- Some women feel better when low testosterone is treated, while others need mood treatment more than hormone treatment
Depression itself can also affect hormones, sleep, and sex drive. So you can end up with both conditions at the same time.
This is why many OB-GYNs use blood tests and short depression screening questions together. For more background, you can read about how hormones affect women’s mental health.
Having both low testosterone and depression does not mean you are weak. It simply means your body and mind both need care.
When to See Your Chicago OB-GYN and What Testing Looks Like
You do not have to wait until you hit rock bottom to ask for help. In fact, it is better if you do not.
At a clinic like the Women’s Health Center of Chicago on Fullerton Avenue, you can talk about mood, sex, sleep, and energy in one visit.
Signs it is time to talk with your OB-GYN about low T or depression
Make an appointment if you notice:
- Symptoms lasting longer than two weeks
- Feelings that are getting worse over time
- Painful sex, very low sex drive, or new vaginal dryness
- Big changes in sleep, energy, or focus
- Trouble keeping up with work, school, or caring for yourself or your family
If you are near menopause, already in menopause, or you recently had a baby, hormone shifts are common. You do not have to feel shy or embarrassed about bringing them up. Your OB-GYN talks about these topics every day.
Early care often means more options and faster relief.
How your doctor checks your hormones and mood in one visit
At your visit, your OB-GYN will likely:
- Ask about your symptoms, cycles, pregnancies, and menopause status
- Review your medical history, medicines, and family history
- Talk about sleep, stress, movement, and substance use
- Do a physical and pelvic exam
- Order blood tests to check testosterone and other hormones, such as estrogen or thyroid
- Have you fill out a short screening form about mood and anxiety
Once the results are back, you and your doctor can build a plan together. That plan may include:
- Hormone treatment or birth control options
- Lifestyle changes for sleep, stress, and movement
- Mental health support, such as therapy or medication
- Regular follow up visits to see how you are feeling
At a practice focused on women’s health, your care is not one size fits all. It is shaped around your body, your story, and your goals.
Conclusion
Low testosterone and depression can look very similar, especially for women in Chicago moving through perimenopause, menopause, or the postpartum period. The overlap in tiredness, low mood, and low sex drive makes it easy to feel stuck and confused. The good news is that both conditions are treatable.
You do not have to ignore low energy, low mood, or sexual changes and hope they pass. Talk openly with a trusted Chicago OB-GYN about what you are feeling in your body and in your mind. With the right tests, support, and follow up, you can find the real cause and start to feel like yourself again. If you have questions about hormones or mood, consider scheduling a visit with a women’s health specialist in Chicago and take the next step toward relief.






